- Graduated from the Medical School of the National and Kapodistrian University of Athens [Ptychio Iatrikes – Diploma in Medicine (MD) (Honours)]
- Specialty training in General (Internal) Medicine and Intensive Care Medicine
- Senior Clinical Fellow in General Critical Care and Neurocritical Care - Addenbrookes Hospital Cambridge
- Consultant in Intensive Care Medicine
- Academic research Fellow 2003-2006 University of Patras Medical School and Imperial college St Mary's Campus
- PhD and postdoctoral academic research fellow 2007-2014 University of Athens Medical School
Qualifications
Academic Qualifications
- Ptychio Iatrikes – Diploma in Medicine [MD]. 2002. Medical School: National and Kapodistrian University of Athens, School of Health Sciences, Faculty of Medicine
- PhD Degree in Medicine [Pharmacogenomics]. 2012 PhD Thesis: “Study of effect of single nucleotide polymorphisms and expression of ERCC1 gene on treatment outcome of advanced Urothelial cancer patients treated with platinum-based chemotherapy” National and Kapodistrian University of Athens, School of Health Sciences, Faculty of Medicine
- MSc in Basic Medical Sciences Applications – Genomics. 2006. MSc Thesis: “Study of Molecular variations in the Core Promoter, Precore, and Core regions of Hepatitis B virus genome, and within the antigenic epitopes of HBcAg in viral strains isolated from Asymptomatic Carriers of the Hepatitis B Virus” University of Patras, Department of Medicine. Laboratory Research conducted at Imperial College London St Mary’s Campus
Clinical Qualifications
- Associate Fellowship in Intensive Care Medicine [AFICM]
- Associate Membership of the Royal College of Physicians
- European Diploma in Intensive Care Medicine, EDIC [European Society of Intensive Care Medicine]
- Specialty Certificate in Intensive Care Medicine
- Specialty Certificate in General [Internal] Medicine
- Educational Supervisor Accreditation [RCP]
- Focused Intensive Care Echocardiography [FICE] Accreditation – FICE Mentor
Professional membership
Associate Fellowship in Intensive Care Medicine [AFICM]
Associate Membership of the Royal College of Physicians
European Diploma in Intensive Care Medicine, EDIC [European Society of Intensive Care Medicine]
Fully registered medical practitioner with a license to practise in the UK and on the specialist register
Teaching
Teaching interests
- Undergraduate clinical medical teaching in Year 5, Year 4 medical students, Intercalated students in Critical Care, Elective students in Critical care
- Mentor of Intercalated students in Critical care
- Clinical Teacher Lead for Intensive Care Medicine - Derriford Hospital
- Evidence in Practice Facilitator - Peninsula Medical school
Research
Research interests
- Somatosensory Evoked Potentials in Neurological Prognostication after cardiac arrest [current project]
- Assessment and monitoring of Interstitial Tissue biochemistry in Critically ill patients by the use of Adipose Tissue Microdialysis
- Study of the effect of single nucleotide polymorphisms in treatment response
- Endocrine Dysregulation in Subarachnoid Haemorrhage
- Viral reactivation in immunocompetent critically ill patients
Clinical research lead for Critical Care Medicine - Derriford Hospital
Other research
Research Experience – Research Projects
Current research project
P25/30 Somatosensory Evoked Potentials and neurological outcome in comatose survivors of Out of Hospital Cardiac Arrest who are not treated with hypothermic targeted temperature management. University Hospitals Â鶹´«Ă˝ NHS Trust, Departments of Intensive Care Medicine and Neurophysiology. Chief investigator of the study
Past Research Projects:“Assessment and monitoring of Interstitial Tissue biochemistry in Critically ill patients by the use of Adipose Tissue Microdialysis”.Post-doctoral research fellowship
“Study of CMV reactivation in adult immunocompetent critically ill patients treated in a General Adult Intensive Care Unit” Post-doctoral research fellowship
PhD Thesis: “Study of effect of single nucleotide polymorphisms and expression of ERCC1 gene on treatment outcome of advanced Urothelial cancer patients treated with platinum-based chemotherapy”
MSc Dissertation: “Study of Molecular variations in the Core Promoter, Precore, and Core regions of Hepatitis B virus genome, and within the antigenic epitopes of HBcAg in viral strains isolated from Asymptomatic Carriers of the Hepatitis B Virus”
Local PI of the following clinical trials:
REMAP – CAP: Randomised, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia
International multi-centre randomised clinical trial – NIHR priority study for the COVID-19 Pandemic
BLING III study - Beta-Lactam InfusioN Group Study
GENOMICC study – Genetics of Mortality In Critical Care
PHIND study: Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
Current research project
P25/30 Somatosensory Evoked Potentials and neurological outcome in comatose survivors of Out of Hospital Cardiac Arrest who are not treated with hypothermic targeted temperature management. University Hospitals Â鶹´«Ă˝ NHS Trust, Departments of Intensive Care Medicine and Neurophysiology. Chief investigator of the study
Past Research Projects:“Assessment and monitoring of Interstitial Tissue biochemistry in Critically ill patients by the use of Adipose Tissue Microdialysis”.Post-doctoral research fellowship
“Study of CMV reactivation in adult immunocompetent critically ill patients treated in a General Adult Intensive Care Unit” Post-doctoral research fellowship
PhD Thesis: “Study of effect of single nucleotide polymorphisms and expression of ERCC1 gene on treatment outcome of advanced Urothelial cancer patients treated with platinum-based chemotherapy”
MSc Dissertation: “Study of Molecular variations in the Core Promoter, Precore, and Core regions of Hepatitis B virus genome, and within the antigenic epitopes of HBcAg in viral strains isolated from Asymptomatic Carriers of the Hepatitis B Virus”
Local PI of the following clinical trials:
REMAP – CAP: Randomised, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia
International multi-centre randomised clinical trial – NIHR priority study for the COVID-19 Pandemic
BLING III study - Beta-Lactam InfusioN Group Study
GENOMICC study – Genetics of Mortality In Critical Care
PHIND study: Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2023) 'Enhanced analysis of somatosensory evoked potentials at 20–30 milliseconds can predict neurological outcome after cardiac arrest' Clinical Neurophysiology 153, 141-151 ,
(2022) 'Endocrine dysregulation in aneurysmal subarachnoid haemorrhage' British Journal of Neurosurgery 36, (3) 358-367 ,
(2020) 'Genetic mechanisms of critical illness in COVID-19' Nature 591, (7848) 92-98 ,
(2020) 'A case of COVID-19 reinfection in the UK' Clinical Medicine 21, (1) e52-e53 ,
(2020) 'Herpes simplex encephalitis following successful coiling of aneurysmal subarachnoid haemorrhage' British Journal of Neurosurgery 37, (5) 1269-1270 ,
(2020) 'Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19' JAMA 324, (13) 1317-1317 ,
(2019) 'Multiple Organ Dysfunction Syndrome' Journal of Intensive Care Medicine 35, (12) 1564-1575 ,
(2018) 'Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness' Metabolites 8, (4) 62-62 ,
(2018) 'Microdialysis-Assessed Adipose Tissue Metabolism in Critically Ill Patients' Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 11, (1) 32-38 ,